POSTDOCTORAL POSITION IN MEDICINAL CHEMISTRY

Postdoctoral position in Medicinal Chemistry - (2400007V) Commitment & contract: collaboration contract Location: Genova - CCT - Via Morego, 30, 16163 Genova GE ABOUT US At IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society. Our Genoa headquarters are strictly interconnected with the other 11 centers around Italy and two outstations based in the US. We promote excellence in basic and applied research such as neuroscience and cognition, humanoid technologies and robotics, nanotechnology, materials for a truly multidisciplinary scientific experience. YOUR TEAM You will be working in a multicultural and multi-disciplinary group, where computational scientists in the fields ranging from physics, to chemistry, to engineering collaborate, each with their own expertise, to carry out common research. The position is at the Computational and Chemical Biology Research Unit led by Prof. Andrea Cavalli. The position is for Postdocs with extensive hands-on research experience in medicinal chemistry, particularly in the design, synthesis, and characterization of bioactive small molecules. The role requires significant experience with diverse synthetic methodologies and compound optimization techniques. Candidates should have a keen interest in integrating a diverse array of complementary computational, biophysical, cellular, and analytical data to assess compound activity and efficacy, facilitating further development. Responsibilities also include publishing results in scientific journals, presenting findings at conferences, and mentoring PhD students. Additionally, the role involves staying current with advancements in medicinal chemistry and contributing to grant writing for research funding. This position is ideal for developing expertise in drug discovery and translational science. The successful candidate will play relevant roles in drug discovery projects, contributing to the design, synthesis, and optimization of novel therapeutic compounds. He/she will work collaboratively with multidisciplinary teams to identify biological targets and develop high-affinity molecules through structure-activity relationship (SAR) studies. The candidate will utilize advanced medicinal chemistry techniques to enhance the potency, selectivity, and pharmacokinetic properties of hit and lead compounds. Additionally, he/she will participate in data analysis and interpretation to guide decision-making, ultimately supporting the transition of promising candidates into preclinical development. Specific activities are: Design and synthesize novel compounds to support drug discovery, applying medicinal chemistry principles to optimize pharmacological properties and implementing innovative synthetic strategies for efficiency and scalability. Perform SAR studies to refine hit and lead compounds. Utilize advanced analytical techniques, including HPLC, LC-MS, NMR, and other methods to characterize and purify compounds. Work within cross-functional teams to integrate chemistry efforts, contributing to experiment planning and execution aligned with project goals. Stay updated on scientific advancements with literature search software, applying new approaches to solve complex challenges and develop fresh research strategies. Keep accurate records of experiments, preparing scientific reports, manuscripts, and presentations for internal and external meetings. ESSENTIAL REQUIREMENTS PhD degree in organic synthesis, synthetic medicinal chemistry, or pharmaceutical sciences. Minimum of 1-2 years of experience in medicinal and/or organic chemistry. Proven track record of successful compound design, synthesis, and optimization and demonstrated ability to design and execute experiments independently. Technical Skills: Proficiency in organic synthetic and purification techniques as well as analytical methods, including NMR, MS, HPLC, and other relevant technologies. Willingness to take on diverse tasks and responsibilities as needed. Excellent English communication skills, creativity, and marked enthusiasm for research. Ability to work independently and collaboratively in a highly interdisciplinary environment. ADDITIONAL SKILLS Good communication skills. Strong problem-solving attitude. Spirit of innovation and creativity. Good in time and priority management. Ability to tutor students and give lectures. COMPENSATION PACKAGE Competitive salary package for international standards. Private health care coverage. Wide range of staff discounts. Candidates from abroad or Italian citizens who permanently work abroad and meet specific requirements may be entitled to a deduction from taxable income of up to 90% from 6 to 13 years. WHAT’S IN FOR YOU? An equal, inclusive, and multicultural environment ready to welcome you with open arms. Discrimination is a big NO for us! We like contamination and encourage you to mingle and discover what other people are up to in our labs! If paperwork is not your piece of cake, we got you! There’s a specialized team working to help you with that, especially during your relocation! If you are a startupper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations. If you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society! We stick to our values! Integrity, courage, societal responsibility, and inclusivity are the values we believe in! They define us and our actions in our everyday life. They guide us to accomplish IIT mission! If you feel this tickles your appetite for change, do not hesitate and apply! Please submit your application using the online form and including a detailed CV, university transcripts, cover letter (outlining motivation, experience, and qualifications) and contact details of 2 references. Application’s deadline: December 31st 2024 We inform you that the information you provide will be used solely for the purposes of evaluating and selecting professional profiles in order to meet the requirements of Istituto Italiano di Tecnologia. Your data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security. Please also note that, pursuant to articles 15 et. seq. of European Regulation no. 679/2016 (General Data Protection Regulation), you may exercise your rights at any time by contacting the Data Protection Officer (phone Tel: +39 010 28961) email: ... - kindly note that this e-mail address is exclusively reserved for handling data protection issues. Please, do not use this e-mail address to send any document and/or request of information about this opening). Primary Location: GENOVA Job: Postdoc Organization: Computational and Chemical Biology Job Posting: Oct 31, 2024, 5:32:36 AM #J-18808-Ljbffr