PRINCIPAL SCIENTIST MSAT

At Johnson & Johnson, we believe health is everything.
Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.
Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
Learn more at https://www.
nj.
om/.
The Principal Scientist position will be based in the small molecule drug substance labs as part of Manufacturing Science and Technology (MSAT).
The position supports a multi-functional team in developing and deliver solutions required to maintain continued supply of Johnson and Johnson innovative medicines.
The position primarily supports the Life Cycle Management (LCM) portfolio by planing and performing lab-based activities in support of ongoing manufacturing as well as to tackle manufacturing issues.
The applicant will be working in close collaboration with our partners in MSAT Innovation and technology department, R&D, quality and our external network.
This individual will have technical leadership and support responsibilities throughout the product life cycle.
They will.
Provide organic and process chemistry expertise leverage the collaboration with multiple partners to develop more cost efficient syntheses of regulatory starting materials assess existing processes for their cost-improvement potential develop, plan, lead and complete lab-based activities, mimicking full scale process performance, performing root cause analysis experiments, use-tests, or reprocess testing/development).
transfer sophisticated processes, manufacturing technologies, analytical technologies to multiple sites and other laboratories.
evaluate process and process analytical technology (PAT) data to define experimental activities to understand and resolve manufacturing issues.
Lead or support process capability and quality improvement efforts on new or marketed products.
Qualifications COMPETENCY (knowledge, skills, abilities, and experience).
Candidates should have excellent organic chemistry knowledge and the necessary laboratory skills with emphasis on.
Chemical process development New synthetic route definitions Analysis and interpretation of data Experience with analytical tools (U/HPLC, GC, NMR) Technical writing for the generation of technical reports Use of electronic lab notebook systems and instrument logbooks Experience with process analytical technologies (PAT) like FTIR, FBRM, Raman Spectroscopy would be highly desired.
Experience with operational responsibilities of a laboratory, including purchasing materials, equipment set up/operation, management of chemicals, which may include controlled substances.
experience with document control systems and change control systems is helpful or the willingness to learn Basic understanding of statistical methods and statistical process control.
Understanding of good manufacturing practice (GMP).
Ability to seek out and engage with various partners both globally and on-site.
Laboratory safety practices and response procedures, Holds a PhD in organic chemistry and at least 5 years laboratory experience in process development in the pharmaceutical or chemical industry.
Languages.
Proficient in written and spoken English.
Specific systems.
Microsoft Office, Minitab, Lab Note book, Lab systems eg HPLC, GC Physical requirements/working conditions.
Main location.
Schaffhausen Works in an international environment across different time zones.
Travel.
This position requires up to 10 % (domestic and international) travel.