FELLOW SENIOR POSITION EARLY RETINAL NEURODEGENERATION AS RISK FACTOR, BIOMARKER AND PHARMACOLOGICAL TARGET OF DIABETIC RETINOPATHY (X)

Commitment %26amp; contract.
collaboration contract for one-month (January )Location.
Center for Synaptic Neuroscience and Technology, Genova, Italy WHO WE AREAt IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society.
Our Genoa headquarter is strictly inter-connected with our 11 centers around Italy and two outer-stations based in the US for a truly interdisciplinary experience.
OUR TEAM You will be working in a multicultural and multi-disciplinary group, where biomedical engineers, biologists, physicists, chemists, biotechnologists, and computational scientists collaborate, each with their own expertise, to carry out common research.
The Neuroscience and Smart Materials Research Unit is coordinated by Prof.
Fabio Benfenati, who has extensive experience in biomedicine, neurophysiology, and neural interfaces.
The research focuses on the neuronal physiopathological mechanisms that lead to diabetic retinopathy.
espite the evidence that diabetic retinopathy (DR) still remains the first cause of blindness among the working-age population, it lacks a specific preventive treatment.
This is due to the fact that early mechanisms leading to the development of DR have been, until recently, unknown.
Recent findings have shown that DR is preceded by retinal neurodegeneration focused on retinal ganglion cells.
The aim of this project will be to verify whether neurodegeneration could represent a pharmacologic target.
A specific therapeutic intervention during this early phase of DR could allow, for the first time, to prevent complications by acting on the initial pathogenetic mechanisms.
However, it remains to be clarified whether an early anti-inflammatory or antioxidant therapy (or combination of both) in the course of diabetes is actually able to prevent DR.
To this end, the use of molecules of natural origin for their proven tolerability and ability to interact with crucial molecular pathways of inflammation is becoming increasingly interesting.
In particular, the proposing group has proven experience in the use of Repron saffron (saffron that naturally has particular concentrations of its constituent molecules such as to provide neuroprotective effects, under patent) as a food supplement for the prevention and mitigation of degeneration of photoreceptors.
Retinal dysfunction will be evaluated.
ithin the team, your main responsibilities will be.
ontribute to the experiments to test the efficacy of Saffron Repron%26copy; in preventing diabetic retinopathy.
his open position is financed by the Ministry of Health/PNRR-Next Generation EU (Project Code.
PNRR-MAD--) "Early Retinal Neurodegeneration as Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy" CUP J53C, admitted to funding by the Ministry of Health for the implementation of Investment 2.
- Enhancement and strengthening of biomedical research of the NHS - as part of Mission 6 "Health", Component C2 "of the National Recovery and Resilience Plan.
HAT WOULD MAKE YOU SHINEA PhD in Biotechnology, Molecular Biology, Neuroscience or similar Documented experience in Neurophysiology A strong publication recordThe ability to properly report, organize and publish research dataGood command in spoken and written EnglishEXTRA AWESOMEKnowledge of retinal physiology Knowledge and experience in in-vivo retinal electrophysiologyGood communication skills Strong problem-solving attitudeHigh motivation to learnSpirit of innovation and creativityGood in time and priority managementAbility to work in a challenging and international environmentAbility to work independently and collaboratively in a highly interdisciplinary environmentCOMPENSATION %26amp; BENEFITSCompetitive salary for international standards Wide range of staff discountsWHAT'S IN FOR YOUAnequal,inclusive andmulticulturalenvironmentready to welcome you with open arms.
Discrimination is a big NO for us!Welike contamination andencourage you to mingle and discover what other people are up to in our labs!If paperwork is not your piece of cake, we got you! There's a specialized team working to help you with that, especially during your relocation!If you are a startupper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations.
f you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society!We stick to our values! Integrity, courage, societal responsibility and inclusivity are the values we believe in! They define us and our actions in our everyday life.
They guide us to accomplish IIT mission!If you feel this tickles your appetite for change, do not hesitate and apply!Please submit your application using the online form and including a detailed CV and a cover letter (outlining motivation, experience and qualifications).
pplication's deadline.
November, We inform you that the information you provide will be used solely for the purposes of evaluating and selecting professional profiles in order to meet the requirements of Istituto Italiano di Tecnologia.
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